AbSim

Time Resolved Simulations of Antibody Repertoires

Simulation methods for the evolution of antibody repertoires. The heavy and light chain variable region of both human and C57BL/6 mice can be simulated in a time-dependent fashion. Both single lineages using one set of V-, D-, and J-genes or full repertoires can be simulated. The algorithm begins with an initial V-D-J recombination event, starting the first phylogenetic tree. Upon completion, the main loop of the algorithm begins, with each iteration representing one simulated time step. Various mutation events are possible at each time step, contributing to a diverse final repertoire.

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Description file content

Package
AbSim
Type
Package
Title
Time Resolved Simulations of Antibody Repertoires
Version
0.2.2
Date
2017-6-18
Author
Alexander Yermanos
Maintainer
Alexander Yermanos
Depends
R(>= 3.1.0), ape, poweRlaw
Description
Simulation methods for the evolution of antibody repertoires. The heavy and light chain variable region of both human and C57BL/6 mice can be simulated in a time-dependent fashion. Both single lineages using one set of V-, D-, and J-genes or full repertoires can be simulated. The algorithm begins with an initial V-D-J recombination event, starting the first phylogenetic tree. Upon completion, the main loop of the algorithm begins, with each iteration representing one simulated time step. Various mutation events are possible at each time step, contributing to a diverse final repertoire.
License
GPL-2
Encoding
UTF-8
RoxygenNote
5.0.1
Suggests
knitr, rmarkdown
VignetteBuilder
knitr
NeedsCompilation
no
Packaged
2017-06-18 17:57:25 UTC; ayermano
Repository
CRAN
Date/Publication
2017-06-18 18:14:37 UTC

install.packages('AbSim')

0.2.2

2 months ago

Alexander Yermanos

GPL-2

Depends on

R(>= 3.1.0), ape, poweRlaw

Suggests

knitr, rmarkdown

Discussions