IAbin

Plotting N-T Plane for Decision on Performing an Interim Analysis

In randomized-controlled trials, interim analyses are often planned for possible early trial termination to claim superiority or futility of a new therapy. Blinded data also have information about the potential treatment difference between the groups. We developed a blinded data monitoring tool that enables investigators to predict whether they observe such an unblinded interim analysis results that supports early termination of the trial. Investigators may skip some of the planned interim analyses if an early termination is unlikely. This tool will provide reference information about N: Sample size at interim analysis, and T: Total number of responders at interim analysis for decision on performing an interim analysis.

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Description file content

Package
IAbin
Type
Package
Title
Plotting N-T Plane for Decision on Performing an Interim Analysis
Version
1.0
Date
2017-08-11
Author
Kyongsun Pak
Maintainer
Kyongsun Pak
Description
In randomized-controlled trials, interim analyses are often planned for possible early trial termination to claim superiority or futility of a new therapy. Blinded data also have information about the potential treatment difference between the groups. We developed a blinded data monitoring tool that enables investigators to predict whether they observe such an unblinded interim analysis results that supports early termination of the trial. Investigators may skip some of the planned interim analyses if an early termination is unlikely. This tool will provide reference information about N: Sample size at interim analysis, and T: Total number of responders at interim analysis for decision on performing an interim analysis.
License
GPL (>= 2)
VignetteBuilder
knitr
RoxygenNote
6.0.1
Suggests
testthat, evaluate, knitr
Imports
graphics, stats
NeedsCompilation
no
Packaged
2017-08-11 18:17:36 UTC; pakk
Repository
CRAN
Date/Publication
2017-08-11 18:52:55 UTC

install.packages('IAbin')

1.0

2 months ago

Kyongsun Pak

GPL (>= 2)

Imports

graphics, stats

Suggests

testthat, evaluate, knitr

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