MetaSubtract

Subtracting Summary Statistics of One or more Cohorts from Meta-GWAS Results

If results from a meta-GWAS are used for validation in one of the cohorts that was included in the meta-analysis, this will yield biased (i.e. too optimistic) results. The validation cohort needs to be independent from the meta-Genome-Wide-Association-Study (meta-GWAS) results. 'MetaSubtract' will subtract the results of the respective cohort from the meta-GWAS results analytically without having to redo the meta-GWAS analysis using the leave-one-out methodology. It can handle different meta-analyses methods and takes into account if single or double genomic control correction was applied to the original meta-analysis. It can also handle different meta-analysis methods. It can be used for whole GWAS, but also for a limited set of genetic markers.

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Description file content

Package
MetaSubtract
Type
Package
Title
Subtracting Summary Statistics of One or more Cohorts from Meta-GWAS Results
Version
1.43
Date
2018-07-10
Author
Ilja M. Nolte
Maintainer
Ilja M. Nolte
Description
If results from a meta-GWAS are used for validation in one of the cohorts that was included in the meta-analysis, this will yield biased (i.e. too optimistic) results. The validation cohort needs to be independent from the meta-Genome-Wide-Association-Study (meta-GWAS) results. 'MetaSubtract' will subtract the results of the respective cohort from the meta-GWAS results analytically without having to redo the meta-GWAS analysis using the leave-one-out methodology. It can handle different meta-analyses methods and takes into account if single or double genomic control correction was applied to the original meta-analysis. It can also handle different meta-analysis methods. It can be used for whole GWAS, but also for a limited set of genetic markers.
License
GPL (>= 3)
NeedsCompilation
no
Packaged
2018-07-10 10:50:34 UTC; NolteIM
Repository
CRAN
Date/Publication
2018-07-10 11:10:04 UTC

install.packages('MetaSubtract')

1.43

3 months ago

Ilja M. Nolte

GPL (>= 3)

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