Phase123

Simulating and Conducting Phase 123 Trials

Contains three simulation functions for implementing the entire Phase 123 trial and the separate Eff-Tox and Phase 3 portions of the trial, which may be beneficial for use on clusters. The functions AssignEffTox() and RandomizeEffTox() assign doses to patient cohorts during phase 12 and Reoptimize() determines the optimal dose to continue with during Phase 3. The functions ReturnMeansAgent() and ReturnMeanControl() gives the true mean survival for the agent doses and control and ReturnOCS() gives the operating characteristics of the design.

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Description file content

Package
Phase123
Type
Package
Title
Simulating and Conducting Phase 123 Trials
Version
2.0
Date
2018-10-8
Author
Andrew G Chapple
Maintainer
Andrew G Chapple
Description
Contains three simulation functions for implementing the entire Phase 123 trial and the separate Eff-Tox and Phase 3 portions of the trial, which may be beneficial for use on clusters. The functions AssignEffTox() and RandomizeEffTox() assign doses to patient cohorts during phase 12 and Reoptimize() determines the optimal dose to continue with during Phase 3. The functions ReturnMeansAgent() and ReturnMeanControl() gives the true mean survival for the agent doses and control and ReturnOCS() gives the operating characteristics of the design.
License
GPL-2
Encoding
UTF-8
LazyData
true
Imports
Rcpp (>= 0.12.9),survival, stats
LinkingTo
Rcpp, RcppArmadillo
RoxygenNote
6.1.0
NeedsCompilation
yes
Packaged
2018-11-08 19:04:58 UTC; Andrew
Repository
CRAN
Date/Publication
2018-11-09 14:30:50 UTC

install.packages('Phase123')

2.0

8 days ago

Andrew G Chapple

GPL-2

Imports

Rcpp (>= 0.12.9),survival, stats

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