RNOmni

Omnibus Test for Genetic Association Analysis using the Rank Normal Transformation

Implementation of genetic association tests that utilize the rank based inverse normal transformation (INT). The primary contribution is an omnibus test, which synthesizes two INT-based approaches, termed direct INT (DINT) and partially indirect INT (PIINT). In genome scale simulations, the omnibus test routinely provided valid inference against continuous phenotypes with skewed and heavy tailed residual distributions. Association testing against these same phenotypes via standard linear regression led to an excess of false positive associations. In addition to controlling the type I error, the omnibus approach provided power comparable to the more powerful of the component methods.

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Description file content

Package
RNOmni
Title
Omnibus Test for Genetic Association Analysis using the Rank Normal Transformation
Version
0.1.5
Date
2018-02-12
Description
Implementation of genetic association tests that utilize the rank based inverse normal transformation (INT). The primary contribution is an omnibus test, which synthesizes two INT-based approaches, termed direct INT (DINT) and partially indirect INT (PIINT). In genome scale simulations, the omnibus test routinely provided valid inference against continuous phenotypes with skewed and heavy tailed residual distributions. Association testing against these same phenotypes via standard linear regression led to an excess of false positive associations. In addition to controlling the type I error, the omnibus approach provided power comparable to the more powerful of the component methods.
Depends
R (>= 3.2.2)
Imports
abind, foreach, mvtnorm, RcppEigen
License
GPL-2
Encoding
UTF-8
LazyData
true
RoxygenNote
6.0.1.9000
Suggests
cowplot, ggplot2, knitr, reshape2, rmarkdown
VignetteBuilder
knitr
NeedsCompilation
no
Packaged
2018-02-12 20:28:50 UTC; zmccaw
Author
Zachary McCaw [aut, cre]
Maintainer
Zachary McCaw
Repository
CRAN
Date/Publication
2018-02-12 23:30:29 UTC

install.packages('RNOmni')

0.1.5

6 days ago

Zachary McCaw

GPL-2

Depends on

R (>= 3.2.2)

Imports

abind, foreach, mvtnorm, RcppEigen

Suggests

cowplot, ggplot2, knitr, reshape2, rmarkdown

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