RNOmni

Omnibus Test for Genetic Association Analysis using the Rank Normal Transformation

Implementation of genetic association tests using the rank based inverse normal transformation (INT). The primary contribution is an omnibus test, which synthesizes two complementary INT-based approaches. In simulations against phenotypes with skewed and heavy tailed residuals, the omnibus test provided valid inference in the absence of genetic effects. When genetic effects were present, the omnibus test provided power comparable to the more efficient of the component methods. Under these settings, standard linear regression variously failed to control the type I error in the absence of genetic effects, and was underpowered in the presence of genetic effects.

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Description file content

Package
RNOmni
Title
Omnibus Test for Genetic Association Analysis using the Rank Normal Transformation
Version
0.4.0
Date
2018-05-16
Description
Implementation of genetic association tests using the rank based inverse normal transformation (INT). The primary contribution is an omnibus test, which synthesizes two complementary INT-based approaches. In simulations against phenotypes with skewed and heavy tailed residuals, the omnibus test provided valid inference in the absence of genetic effects. When genetic effects were present, the omnibus test provided power comparable to the more efficient of the component methods. Under these settings, standard linear regression variously failed to control the type I error in the absence of genetic effects, and was underpowered in the presence of genetic effects.
Depends
R (>= 3.2.2)
Imports
abind, foreach, mvtnorm, plyr, Rcpp
License
GPL-3
Encoding
UTF-8
LazyData
true
RoxygenNote
6.0.1
Suggests
ggplot2, knitr, reshape2, rmarkdown
VignetteBuilder
knitr
LinkingTo
Rcpp, RcppEigen
NeedsCompilation
yes
Packaged
2018-05-16 19:14:58 UTC; zmccaw
Author
Zachary McCaw [aut, cre]
Maintainer
Zachary McCaw
Repository
CRAN
Date/Publication
2018-05-16 21:38:13 UTC

install.packages('RNOmni')

0.4.0

2 months ago

Zachary McCaw

GPL-3

Depends on

R (>= 3.2.2)

Imports

abind, foreach, mvtnorm, plyr, Rcpp

Suggests

ggplot2, knitr, reshape2, rmarkdown

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