RNOmni

Rank Normal Transformation Omnibus Test

Implementation of genetic association tests that incorporate the rank-based inverse normal transformation (INT). These tests are broadly indicated for traits with continuous residual distributions. In the presence of non-normal residuals, INT-based tests robustly control the type I error, whereas standard linear regression may not. Moreover, INT-based tests dominate standard linear regression in terms of power. There are two main strategies for incorporating the INT in association analysis. In direct INT (D-INT), the trait is directly transformed. In indirect INT (I-INT), residuals are formed prior to transformation. Neither D-INT nor I-INT is uniformly most powerful. The INT omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach.

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Description file content

Package
RNOmni
Title
Rank Normal Transformation Omnibus Test
Version
0.6.0
Date
2019-01-12
Description
Implementation of genetic association tests that incorporate the rank-based inverse normal transformation (INT). These tests are broadly indicated for traits with continuous residual distributions. In the presence of non-normal residuals, INT-based tests robustly control the type I error, whereas standard linear regression may not. Moreover, INT-based tests dominate standard linear regression in terms of power. There are two main strategies for incorporating the INT in association analysis. In direct INT (D-INT), the trait is directly transformed. In indirect INT (I-INT), residuals are formed prior to transformation. Neither D-INT nor I-INT is uniformly most powerful. The INT omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach.
Depends
R (>= 3.2.2)
Imports
abind, foreach, plyr, Rcpp
License
GPL-3
Encoding
UTF-8
LazyData
true
RoxygenNote
6.1.0
Suggests
cowplot, ggplot2, knitr, reshape2, rmarkdown
VignetteBuilder
knitr
LinkingTo
Rcpp, RcppEigen
NeedsCompilation
yes
Packaged
2019-01-12 05:20:36 UTC; zmccaw
Author
Zachary McCaw [aut, cre]
Maintainer
Zachary McCaw
Repository
CRAN
Date/Publication
2019-01-12 22:21:21 UTC

install.packages('RNOmni')

0.6.0

a month ago

Zachary McCaw

GPL-3

Depends on

R (>= 3.2.2)

Imports

abind, foreach, plyr, Rcpp

Suggests

cowplot, ggplot2, knitr, reshape2, rmarkdown

Discussions