Surrogate

Evaluation of Surrogate Endpoints in Clinical Trials

In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness of a new therapy (the true endpoint) is difficult to measure. In such a situation, it can be an effective strategy to replace the true endpoint by a (bio)marker that is easier to measure and that allows for a prediction of the treatment effect on the true endpoint (a surrogate endpoint). The package 'Surrogate' allows for an evaluation of the appropriateness of a candidate surrogate endpoint based on the meta-analytic, information-theoretic, and causal-inference frameworks. Part of this software has been developed using funding provided from the European Union's Seventh Framework Programme for research, technological development and demonstration under Grant Agreement no 602552.

Total

27,774

Last month

483

Last week

111

Average per day

16

Daily downloads

Total downloads

Description file content

Package
Surrogate
Type
Package
Title
Evaluation of Surrogate Endpoints in Clinical Trials
Version
1.1
Author
Wim Van der Elst, Paul Meyvisch, Alvaro Florez Poveda, Ariel Alonso, Hannah M. Ensor, Christopher J. Weir & Geert Molenberghs
Maintainer
Wim Van der Elst
Description
In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness of a new therapy (the true endpoint) is difficult to measure. In such a situation, it can be an effective strategy to replace the true endpoint by a (bio)marker that is easier to measure and that allows for a prediction of the treatment effect on the true endpoint (a surrogate endpoint). The package 'Surrogate' allows for an evaluation of the appropriateness of a candidate surrogate endpoint based on the meta-analytic, information-theoretic, and causal-inference frameworks. Part of this software has been developed using funding provided from the European Union's Seventh Framework Programme for research, technological development and demonstration under Grant Agreement no 602552.
Depends
MASS, msm
Imports
rgl, lattice, latticeExtra, survival, nlme, lme4, OrdinalLogisticBiplot, logistf, rms, mixtools, parallel, ks, rootSolve, extraDistr
License
GPL (>= 2)
Repository
CRAN
NeedsCompilation
no
Packaged
2018-10-18 18:58:26 UTC; wim
Date/Publication
2018-10-18 19:50:03 UTC

install.packages('Surrogate')

1.1

2 months ago

Wim Van der Elst

GPL (>= 2)

Depends on

MASS, msm

Imports

rgl, lattice, latticeExtra, survival, nlme, lme4, OrdinalLogisticBiplot, logistf, rms, mixtools, parallel, ks, rootSolve, extraDistr

Discussions