mrMLM

Multi-Locus Random-SNP-Effect Mixed Linear Model Tools for Genome-Wide Association Study

Conduct multi-locus genome-wide association study under the framework of random-SNP-effect mixed linear model (mrMLM). First, each marker on the genome is scanned. Bonferroni correction is replaced by a less stringent selection criterion for significant test. Then, all the markers that are potentially associated with the trait are included in a multi-locus model, their effects are estimated by empirical Bayes and true QTN are identified by likelihood ratio test. Wen YJ, Zhang H, Ni YL, Huang B, Zhang J, Feng JY, Wang SB, Dunwell JM, Zhang YM, Wu R (2018) <doi:10.1093/bib/bbw145>.

Total

9,268

Last month

312

Last week

85

Average per day

10

Daily downloads

Total downloads

Description file content

Package
mrMLM
Type
Package
Title
Multi-Locus Random-SNP-Effect Mixed Linear Model Tools for Genome-Wide Association Study
Version
3.1
Date
2018-8-25
Author
Zhang Ya-Wen, Li Pei, Ren Wen-Long, Ni Yuan-Li, and Zhang Yuan-Ming
Maintainer
Yuanming Zhang
Description
Conduct multi-locus genome-wide association study under the framework of random-SNP-effect mixed linear model (mrMLM). First, each marker on the genome is scanned. Bonferroni correction is replaced by a less stringent selection criterion for significant test. Then, all the markers that are potentially associated with the trait are included in a multi-locus model, their effects are estimated by empirical Bayes and true QTN are identified by likelihood ratio test. Wen YJ, Zhang H, Ni YL, Huang B, Zhang J, Feng JY, Wang SB, Dunwell JM, Zhang YM, Wu R (2018) .
Depends
MASS,data.table,doParallel,foreach
Imports
methods,openxlsx,stringr,qqman,ggplot2,lars,ncvreg,coin,sampling,bigmemory
License
GPL (>= 2)
NeedsCompilation
no
Packaged
2018-08-25 08:08:42 UTC; Administrator
Repository
CRAN
Date/Publication
2018-08-25 22:10:03 UTC

install.packages('mrMLM')

3.1

3 months ago

Yuanming Zhang

GPL (>= 2)

Depends on

MASS,data.table,doParallel,foreach

Imports

methods,openxlsx,stringr,qqman,ggplot2,lars,ncvreg,coin,sampling,bigmemory

Discussions