wnl

Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis

This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model.

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Package
wnl
Version
0.5.1
Title
Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis
Description
This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model.
Depends
R (>= 3.0.0), numDeriv
Author
Kyun-Seop Bae [aut]
Maintainer
Kyun-Seop Bae
Copyright
2017-, Kyun-Seop Bae
License
GPL-3
NeedsCompilation
no
LazyLoad
yes
Repository
CRAN
URL
Packaged
2019-06-10 15:27:53 UTC; K
Date/Publication
2019-06-10 16:00:03 UTC

install.packages('wnl')

0.5.1

2 months ago

https://cran.r-project.org/package=wnl

Kyun-Seop Bae

GPL-3

Depends on

R (>= 3.0.0), numDeriv

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