RNOmni

Omnibus Test for Genetic Association Analysis using the Rank Normal Transformation

Implementation of genetic association tests for continuous outcomes utilizing the rank-based inverse normal transformation (INT). For outcomes whose residual distribution is heavily skewed or enriched for outliers, INT-based tests provided valid inference and improved power. The primary contribution is a rank normal omnibus test (RNOmni), which synthesizes two complementary INT-based approaches. In simulations against non-normal phenotypes, the omnibus test controlled the type I error in the absence of genetic associations, and improved power in the presence of genetic associations. Under the same settings, standard linear regression variously failed to control the type I error in the absence of associations, and was underpowered in the presence of associations.

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Description file content

Package
RNOmni
Title
Omnibus Test for Genetic Association Analysis using the Rank Normal Transformation
Version
0.5.0
Date
2018-09-13
Description
Implementation of genetic association tests for continuous outcomes utilizing the rank-based inverse normal transformation (INT). For outcomes whose residual distribution is heavily skewed or enriched for outliers, INT-based tests provided valid inference and improved power. The primary contribution is a rank normal omnibus test (RNOmni), which synthesizes two complementary INT-based approaches. In simulations against non-normal phenotypes, the omnibus test controlled the type I error in the absence of genetic associations, and improved power in the presence of genetic associations. Under the same settings, standard linear regression variously failed to control the type I error in the absence of associations, and was underpowered in the presence of associations.
Depends
R (>= 3.2.2)
Imports
abind, foreach, plyr, Rcpp
License
GPL-3
Encoding
UTF-8
LazyData
true
RoxygenNote
6.0.1
Suggests
cowplot, ggplot2, knitr, reshape2, rmarkdown
VignetteBuilder
knitr
LinkingTo
Rcpp, RcppEigen
NeedsCompilation
yes
Packaged
2018-09-13 19:50:49 UTC; zmccaw
Author
Zachary McCaw [aut, cre]
Maintainer
Zachary McCaw
Repository
CRAN
Date/Publication
2018-09-14 07:50:10 UTC

install.packages('RNOmni')

0.5.0

2 months ago

Zachary McCaw

GPL-3

Depends on

R (>= 3.2.2)

Imports

abind, foreach, plyr, Rcpp

Suggests

cowplot, ggplot2, knitr, reshape2, rmarkdown

Discussions