dr4pl

Dose Response Data Analysis using the 4 Parameter Logistic (4pl) Model

Models the relationship between dose levels and responses in a pharmacological experiment using the 4 Parameter Logistic model. Traditional packages on dose-response modelling such as 'drc' and 'nplr' often draw errors due to convergence failure especially when data have outliers or non-logistic shapes. This package provides robust estimation methods that are less affected by outliers and other initialization methods that work well for data lacking logistic shapes. We provide the bounds on the parameters of the 4PL model that prevent parameter estimates from diverging or converging to zero and base their justification in a statistical principle. These methods are used as remedies to convergence failure problems. Gadagkar, S. R. and Call, G. B. (2015) <doi:10.1016/j.vascn.2014.08.006> Ritz, C. and Baty, F. and Streibig, J. C. and Gerhard, D. (2015) <doi:10.1371/journal.pone.0146021>.

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Description file content

Package
dr4pl
Type
Package
Date
2018-09-12
Title
Dose Response Data Analysis using the 4 Parameter Logistic (4pl) Model
Version
1.1.7.1
Depends
R (>= 3.1.0)
Description
Models the relationship between dose levels and responses in a pharmacological experiment using the 4 Parameter Logistic model. Traditional packages on dose-response modelling such as 'drc' and 'nplr' often draw errors due to convergence failure especially when data have outliers or non-logistic shapes. This package provides robust estimation methods that are less affected by outliers and other initialization methods that work well for data lacking logistic shapes. We provide the bounds on the parameters of the 4PL model that prevent parameter estimates from diverging or converging to zero and base their justification in a statistical principle. These methods are used as remedies to convergence failure problems. Gadagkar, S. R. and Call, G. B. (2015) Ritz, C. and Baty, F. and Streibig, J. C. and Gerhard, D. (2015) .
License
GPL (>= 2)
LazyData
TRUE
URL
BugReports
https://bitbucket.org/dittmerlab/dr4pl/issues?status=new&status=open
RdMacros
Rdpack
RoxygenNote
6.0.1
Imports
ggplot2, Matrix, matrixcalc, tensor, Rdpack
Suggests
drc, devtools, roxygen2, testthat, knitr, rmarkdown
VignetteBuilder
knitr
NeedsCompilation
no
Packaged
2018-09-13 22:02:49 UTC; travis
Author
Justin T. Landis [aut, cre], Hyowon An [aut], Aubrey G. Bailey [aut]
Maintainer
Justin T. Landis
Repository
CRAN
Date/Publication
2018-09-13 23:00:03 UTC

install.packages('dr4pl')

1.1.7.1

2 months ago

https://bitbucket.org/dittmerlab/dr4pl

Justin T. Landis

GPL (>= 2)

Depends on

R (>= 3.1.0)

Imports

ggplot2, Matrix, matrixcalc, tensor, Rdpack

Suggests

drc, devtools, roxygen2, testthat, knitr, rmarkdown

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